Qualification in Laboratory Safety Exam Prep
Free practice questions

Free QLS Practice Questions

10 exam-style questions with answers and explanations, straight from our 1,030-question bank. Tap an answer to check yourself. When you're ready, take the scored version in the free practice test.

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The QLS exam has 50 questions and runs 1 hours 30 minutes.

These 10 free QLS questions are organized by exam domain, so you can see how each part of the Qualification in Laboratory Safety blueprint is tested. Reveal the answer and explanation under each question.

Domain 1: Management (18-22%)

Question 1

Blood from an HBsAg-positive patient splashes into an immunocompetent technologist's eye. The technologist irrigates the eye and reports for occupational-health evaluation. Records document a complete hepatitis B vaccine series and an anti-HBs concentration of 82 mIU/mL measured one month after the final dose. A repeat anti-HBs result obtained today is 4 mIU/mL. While other bloodborne risks are assessed, which HBV-specific recommendation is appropriate?

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Correct answer: A - No HBV postexposure prophylaxis is indicated for this documented vaccine responder.

Question 2

An outside service company will replace a valve on a laboratory autoclave. Both the hospital and the contractor have written lockout/tagout procedures, but their procedures differ. What coordination does OSHA require between the two employers before this work?

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Correct answer: B - They exchange procedures, and the hospital ensures its employees understand and follow the contractor's restrictions.

Domain 2: General Safety (18-22%)

Question 3

Which extinguishing agent is appropriate for a fire involving magnesium turnings?

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Correct answer: B - Class D dry powder rated for magnesium.

Question 4

Following a liquid-nitrogen release, a cryogen-storage room's oxygen monitor reads 9.2%. A coworker is visible on the floor inside. Staff have activated emergency response and prevented entry. Which respiratory equipment is appropriate for a trained rescue team entering this oxygen-deficient atmosphere?

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Correct answer: C - A full-face, positive-pressure self-contained breathing apparatus rated for at least 30 minutes.

Domain 3: Chemical Safety (18-22%)

Question 5

Personal monitoring in a histology operation covered by OSHA's formaldehyde standard measures 1.2 ppm for 3 hours and 0.2 ppm for the remaining 5 hours of an 8-hour shift. Separate representative sampling of the highest-exposure 15-minute task measures 1.6 ppm. The employee has no exposure-related symptoms. Which interpretation of the 8-hour exposure and its follow-up is correct?

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Correct answer: D - 0.58 ppm; repeat monitoring at least every six months and offer medical surveillance.

Question 6

During a controlled chemical-resistance test, solvent is detected on the inner surface of a disposable glove. Integrity testing confirms that the glove has no holes or tears. There is no swelling, cracking, or softening, and the cuff has remained dry. Which mechanism accounts for the solvent crossing the barrier?

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Correct answer: D - Permeation through the intact glove material.

Domain 4: Biohazard Control (18-22%)

Question 7

A laboratory adds a xylene-based preparation step to work performed in a certified Class II Type A2 biological safety cabinet. The cabinet returns its HEPA-filtered exhaust to the room. Airflow readings remain normal, but staff notice solvent odor. What should the safety officer conclude?

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Correct answer: C - The cabinet lacks vapor control; the solvent step needs suitable chemical exhaust.

Question 8

A shipping coordinator prepares two separate air shipments for a reference laboratory: an unprocessed sputum specimen being tested for tuberculosis, professionally assessed as an infectious substance that does not meet Category A criteria, and a viable Mycobacterium tuberculosis culture. Under U.S. DOT classification, which UN-number pairing is correct?

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Correct answer: C - Sputum: UN 3373; culture: UN 2814.

Domain 5: Physical Environment (18-22%)

Question 9

An autoclaved laboratory-waste load is awaiting release as treated waste. The chamber record meets the programmed time and temperature, and the external indicator tape has changed color. A correctly placed Geobacillus stearothermophilus biological indicator from within the load is positive; its controls are valid. How should this load be handled?

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Correct answer: A - Quarantine the load and investigate the biological-indicator failure before release.

Question 10

During one calendar month, a laboratory generates 80 kg of nonacute hazardous waste and discards 1.4 kg of a chemical product confirmed to be P-listed acute hazardous waste. There are no acute-spill residues and no applicable episodic-generation or other exemptions. Under the ordinary federal RCRA rules, which generator classification and central-accumulation time limit apply?

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Correct answer: B - Large quantity generator; generally a 90-day accumulation limit.

That's 10 of 1,030

The full bank has 1,020 more QLS questions with explanations.

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